Diffuse Large B-Cell Lymphoma Understanding Symptoms and Treatments
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| Fighting DLBCL-Understanding Treatment Options, Healthnews // Mylymphomateam |
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What is diffuse large b cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is a type of cancer that affects the lymphatic system, which is part of the body's immune system. DLBCL is the most common type of non-Hodgkin lymphoma in adults, accounting for about 30% of all cases.
DLBCL originates in the B-cells, which are white blood cells that help fight infections. In DLBCL, these cells grow uncontrollably and form tumors in the lymph nodes, bone marrow, spleen, liver, or other organs.
The symptoms of DLBCL can include swelling of the lymph nodes, fever, night sweats, unexplained weight loss, fatigue, and difficulty breathing. Treatment for DLBCL typically involves chemotherapy, sometimes in combination with radiation therapy or immunotherapy.
While DLBCL can be a serious and potentially life-threatening condition, many people with this type of lymphoma can achieve remission with appropriate treatment. The prognosis for DLBCL can vary depending on a variety of factors, such as the patient's age and overall health, the stage of the disease, and other medical conditions they may have.
What the causes
The exact cause of diffuse large B-cell lymphoma (DLBCL) is unknown. However, there are several risk factors that may increase a person's chances of developing DLBCL:
- Age: DLBCL is more common in people over the age of 60.
- Weakened immune system: People with weakened immune systems, such as those with HIV/AIDS, organ transplants, or autoimmune diseases, have a higher risk of developing DLBCL.
- Infections: Certain viral and bacterial infections, such as Epstein-Barr virus (EBV), hepatitis C virus (HCV), and Helicobacter pylori (H. pylori), have been linked to an increased risk of DLBCL.
- Genetic factors: Some genetic mutations have been associated with an increased risk of DLBCL.
- Environmental factors: Exposure to certain chemicals or radiation may increase the risk of DLBCL.
It is important to note that having one or more of these risk factors does not necessarily mean that a person will develop DLBCL. Additionally, many people who develop DLBCL do not have any known risk factors.
The symptoms
The symptoms of diffuse large B-cell lymphoma (DLBCL) can vary from person to person, and some people with DLBCL may not experience any symptoms initially. However, the most common symptoms of DLBCL can include:
- Swollen lymph nodes: The most common symptom of DLBCL is the development of swollen lymph nodes, typically in the neck, armpits, or groin.
- Fatigue: Many people with DLBCL experience fatigue or a general feeling of weakness.
- Unexplained weight loss: People with DLBCL may experience unexplained weight loss, typically more than 10% of their body weight.
- Fever: A low-grade fever that comes and goes is a common symptom of DLBCL.
- Night sweats: Some people with DLBCL may experience night sweats, which can be severe enough to soak through clothes and bedding.
- Difficulty breathing: If DLBCL affects the chest area, it can cause difficulty breathing.
- Abdominal pain or swelling: DLBCL can cause abdominal pain or swelling if it affects the organs in the abdomen, such as the liver or spleen.
It is important to note that many of these symptoms can also be caused by other medical conditions, and having one or more of these symptoms does not necessarily mean that a person has DLBCL. However, if you are experiencing any of these symptoms, it is important to see a healthcare provider for an evaluation.
Fighting DLBCL-Understanding Treatment Options, Healthnews // Uchicago medicine
Method of treatment
The treatment for diffuse large B-cell lymphoma (DLBCL) depends on several factors, including the stage of the disease, the patient's age and overall health, and other medical conditions they may have. The following are some of the most common treatment methods used for DLBCL:
- Chemotherapy: This is the main treatment for DLBCL. Chemotherapy uses drugs to kill cancer cells throughout the body. DLBCL is typically treated with a combination of chemotherapy drugs given in cycles, usually every three weeks.
- Radiation therapy: This treatment uses high-energy radiation to kill cancer cells. Radiation therapy may be used in combination with chemotherapy, especially if the cancer is localized.
- Immunotherapy: This treatment uses drugs to help the immune system fight cancer cells. Immunotherapy is sometimes used in combination with chemotherapy or radiation therapy.
- Stem cell transplant: This is a procedure that involves replacing damaged or diseased bone marrow with healthy bone marrow stem cells. This may be an option for some people with DLBCL who have not responded to other treatments.
The treatment plan for DLBCL may also include supportive care, such as medications to manage pain, nausea, or other symptoms, as well as regular check-ups to monitor the disease and manage any potential side effects of treatment.
It is important to discuss treatment options with a healthcare provider who specializes in treating lymphomas to determine the best course of action based on the individual's unique circumstances.
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